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1-aryl-3-aminoalkoxy pyrazoles as sigma ligands enhancing analgesic effect of opioids and attenuating the dependency thereof

机译：1-芳基-3-氨基烷氧基吡唑类作为sigma配体，可增强阿片类药物的镇痛作用并减轻其依赖性

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摘要

The invention relates to the use of a group of sigma receptor ligands of formula (I); embedded image

for the potentiation of the analgesic effect of opioids and opiates and at the same time for decreasing the dependency induced by them.

机译：本发明涉及一组式（I）的σ受体配体的用途; “嵌入式图像”

用于增强阿片类药物和阿片类药物的镇痛作用，同时降低它们所引起的依赖性。

公开/公告号US9914705B2

专利类型
公开/公告日2018-03-13

原文格式PDF
申请/专利权人 LABORATORIOS DEL DR. ESTEVE S.A.;
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申请/专利号US201414502422
发明设计人 HELMUT HEINRICH BUSCHMANN;JOSE MIGUEL VELA-HERNANDEZ;DANIEL ZAMANILLO-CASTANEDO;
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申请日2014-09-30
分类号A61K31/4152;A61K31/4155;A61K31/485;A61K31/5377;C07D231/22;C07D401/12;C07D403/12;C07D471/04;A61K45/06;
国家 US
入库时间 2022-08-21 12:59:20