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SYSTEM AND METHOD FOR IMPROVED ESTIMATION OF FUNCTIONAL POTENTIAL OF GENOMES AND METAGENOMES
SYSTEM AND METHOD FOR IMPROVED ESTIMATION OF FUNCTIONAL POTENTIAL OF GENOMES AND METAGENOMES
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机译:改进的基因组和元命题功能势估计的系统和方法
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摘要
A system and method for estimation of functional potential of pathways in genomes/meta-genomes is provided. Initially seed modules are identified and a multi-dimensional tag map is created. Further, pathway annotation is done using a novel 6Q annotation step. Hidden Markov Model (HMM) based search augmented with an analysis of gene context is used to refine the modules using a graph theory based approach. The method uses the multidimensional module tag map to build a backend knowledge base and use the same for an iterative literature search to verify the clustered organization of genes within a pathway. Finally, a score is assigned to compute the contribution of each pathway within the genome/meta-genome.
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