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MICRO-ORGANISM FOR THE PRODUCTION OF STEREO-SPECIFIC S, S-2,3-BUTANEDIOL
MICRO-ORGANISM FOR THE PRODUCTION OF STEREO-SPECIFIC S, S-2,3-BUTANEDIOL
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机译:用于生产立体特定S,S-2,3-丁二醇的微生物
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摘要
The invention relates to a genetically modified lactic acid bacterium capable of producing (S,S)-2,3-butanediol stereo specifically from glucose under aerobic conditions. Additionally the invention relates to a method for producing (S,S)-2,3-butanediol and L-acetoin using the genetically modified lactic acid bacterium, under aerobic conditions in the presence of a source of iron-containing porphyrin or a source of metal ions (Fe3+/Fe2+). The lactic acid bacterium is genetically modified to express heterologous genes encoding enzymes catalysing the stereo-specific synthesis of (S,S)-2,3-butandiol; and additionally a number of genes are deleted in order to maximise the production of (S,S)-2,3-butanediol as compared to other products of oxidative fermentation.
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机译:本发明涉及能够在有氧条件下特异性地从葡萄糖产生(S,S)-2,3-丁二醇立体的基因修饰的乳酸细菌。另外,本发明涉及使用转基因的乳酸细菌在有氧条件下,在含铁卟啉源或含铁卟啉源的存在下,使用转基因的乳酸细菌生产(S,S)-2,3-丁二醇和L-乙酰丙酮的方法。金属离子(Fe 3 + Sup> / Fe 2 + Sup>)。对乳酸菌进行了基因修饰,以表达编码催化(S,S)-2,3-丁二醇的立体特异性合成的酶的异源基因。与其他氧化发酵产物相比,为了使(S,S)-2,3-丁二醇的产量最大化,还缺失了许多基因。
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