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Haplotying of HLA loci with ultra-deep shotgun sequencing
Haplotying of HLA loci with ultra-deep shotgun sequencing
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机译:用超深度shot弹枪测序对HLA基因座进行单倍型
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摘要
Methods are provided to determine the entire genomic region of a particular HLA locus including both intron and exons. The resultant consensus sequences provides linkage information between different exons, and produces the unique sequence from each of the two genes from the individual sample being typed. The sequence information in intron regions along with the exon sequences provides an accurate HLA haplotype.
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