Time reversal optical tomography for locating targets in a highly scattering turbid medium

摘要

A time reversal optical tomography (TROT) method for near-infrared (NM) diffuse optical imaging of targets embedded in a highly scattering turbid medium is presented. TROT combines the basic symmetry of time reversal invariance and subspace-based signal processing for retrieval of target location. The efficacy of TROT is tested using simulated data and data obtained from NIR imaging experiments on absorptive, scattering and fluorescent targets embedded in Intralipid-20% suspension in water, as turbid medium, as well as, a realistic cancerous model breast assembled using ex vivo human breast tissues with two embedded tumors. The results demonstrate the potential of TROT for detecting and locating small targets in a turbid medium, such as, breast tumors in early stages of growth.