PHARMACEUTICAL FORMULATIONS COMPRISING INSULIN OR INSULIN ANALOGS CONJUGATED TO FUCOSE FOR PROVIDING A BASAL PHARMACODYNAMIC PROFILE

摘要

Disclosed is a pharmaceutical formulation comprising an insulin or insulin analog molecule covalently attached to at least one branched linker having a first arm and second arm, wherein the first arm is linked to a first ligand that includes a first saccharide and the second arm is linked to a second ligand that includes a second saccharide and wherein the first saccharide is fucose. The formulation is suitable for subcutaneous administration and provides a basal pharmacodynamic profile for the insulin oligosaccharide conjugate.