首页> 外国专利> METHOD FOR DETERMINING WHETHER CELLS OR CELL GROUPS ARE DERIVED FROM SAME PERSON, OR UNRELATED PERSONS, OR PARENT AND CHILD, OR PERSONS IN BLOOD RELATIONSHIP

METHOD FOR DETERMINING WHETHER CELLS OR CELL GROUPS ARE DERIVED FROM SAME PERSON, OR UNRELATED PERSONS, OR PARENT AND CHILD, OR PERSONS IN BLOOD RELATIONSHIP

机译:确定是从同一个人,还是无关的人,还是父母和孩子,还是血统关系中的人确定细胞或细胞群的方法

摘要

Provided is a method for determining whether cells or cell groups that have a possibility of being derived from a plurality of persons are derived from the same person, or unrelated persons, or a parent and a child, or persons in a blood relationship, the method including: a step of acquiring genotypic data for gene polymorphism sites of the cells or cell groups and weighting the data with a preset weight distribution, to acquire weighted genotypic data; and a step of using the weighted genotypic data to determine whether the cells or cell groups are derived from the same person, or unrelated persons, or a parent and a child, or persons in a blood relationship, in which the preset weight distribution is set by mapping of a measured apparent genotype and a true genotype with respect to the gene polymorphism sites, and the method being capable of determining, with high accuracy, whether the cells or cell groups are derived from the same person, or unrelated persons, or a parent and a child, or persons in a blood relationship, even in a case where errors due to DNA amplification and sequencing are large and errors frequently occur in thus obtained polymorphism information of genes in genetic analysis for a small amount of deoxyribonucleic acid (DNA).
机译:提供了一种用于确定是否可能从多个人衍生出的细胞或细胞群是从同一个人,无关亲戚,父母和子女,或有血缘关系的人衍生的方法,该方法包括:获取细胞或细胞群的基因多态性位点的基因型数据,并利用预设的权重分布对数据进行加权,以获取加权的基因型数据;使用加权基因型数据确定所述细胞或细胞群是否来自同一人,不相关人,父母和子女,或有血缘关系的人,其中设置了预设的体重分布通过相对于基因多态性位点映射所测得的表观基因型和真实基因型,并且该方法能够高精度地确定细胞或细胞群是来自同一个人,还是无关的人,或父母和孩子,或有血缘关系的人,即使在DNA扩增和测序导致的错误很大且如此获得的基因的多态性信息中经常发生错误的情况下,也需要对少量的脱氧核糖核酸(DNA)进行基因分析。

著录项

  • 公开/公告号US2018247019A1

    专利类型

  • 公开/公告日2018-08-30

    原文格式PDF

  • 申请/专利权人 FUJIFILM CORPORATION;

    申请/专利号US201815964326

  • 发明设计人 TAKAYUKI TSUJIMOTO;

    申请日2018-04-27

  • 分类号G06F19/24;C12Q1/6869;G06F19/22;

  • 国家 US

  • 入库时间 2022-08-21 12:57:15

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