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TOXIC RNAi ACTIVE SEED SEQUENCES FOR KILLING CANCER CELLS
TOXIC RNAi ACTIVE SEED SEQUENCES FOR KILLING CANCER CELLS
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机译:杀死癌细胞的毒性RNAi活性种子序列
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摘要
Disclosed are polynucleotides, compositions, and methods related to RNA interference (RNAi). The disclosed polynucleotides, compositions, and methods may be utilized for treating diseases and disorders through RNAi. Particular disclosed are toxic RNAi active seed sequences and methods of using toxic RNAi active sequences for killing cancer cells. The disclosed toxic RNAi active seed sequences preferentially target and inhibit the expression of multiple essential genes for cell survival and/or growth through a process called “death-induced by survival gene elimination” or “DISE.”
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