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Asynchronous magnetic bead rotation (AMBR) microviscometer for analysis of analytes
Asynchronous magnetic bead rotation (AMBR) microviscometer for analysis of analytes
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机译:异步磁珠旋转(AMBR)微量粘度计用于分析物
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摘要
The disclosure provides a label-free viscosity-based analyte detection system using paramagnetic beads as an asynchronous magnetic bead rotation (AMBR) microviscometer. It is disclosed herein that the bead rotation period is linearly proportional to the viscosity of a solution comprising analytes surrounding the paramagnetic bead. Optical measurement of asynchronous microbead motion determines solution viscosity precisely in microscale volumes, thus allowing an estimate of analyte concentration. The results demonstrate the feasibility of viscosity-based analyte detection using AMBR in microscale aqueous volumes.
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