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Tumor vascular disrupting agent polypeptide, gene, expression vector, and use thereof
Tumor vascular disrupting agent polypeptide, gene, expression vector, and use thereof
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机译:肿瘤血管破坏剂多肽,基因,表达载体及其用途
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摘要
The present invention relates to a tumor vascular disrupting agent polypeptide, gene, expression vector, and use thereof. The tumor vascular disrupting agent polypeptide has the amino acid sequence as shown by SEQ ID NO: 1. The polypeptide comprises a truncated tissue factor (tTF) and a tumor-targeting molecule (pHLIP); the factor and the molecule are connected by 5 amino acids, thereby ensuring the function of each not being affected by the other; the fusion protein can be positioned to the surface of a tumor vascular endothelial cell by means of the pHLIP, and provides the blood coagulation feature of the tTF in a tumor vessel and forms a thrombus, thereby disrupting the blood supply to the tumor area and treating tumor. The polypeptide of the present invention is significant to the treatment of tumor, and can be used in medicines for treating tumors.
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机译:本发明涉及肿瘤血管破坏剂多肽,基因,表达载体及其用途。所述肿瘤血管破坏剂多肽具有如SEQ ID NO:1所示的氨基酸序列。所述多肽包含截短的组织因子(tTF)和肿瘤靶向分子(pHLIP)。因子和分子由5个氨基酸连接,从而确保彼此的功能不受彼此影响。融合蛋白可以通过pHLIP定位在肿瘤血管内皮细胞的表面,并在肿瘤血管中提供tTF的凝血功能,形成血栓,从而破坏了对肿瘤区域的血液供应并治疗瘤。本发明的多肽对于肿瘤的治疗是重要的,并且可以用于治疗肿瘤的药物中。
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