A patient monitoring device includes at least one physiological sensor (32) configured to acquire at least one measured value for a patient of at least one monitored physiological variable. A cardiovascular (CV), pulmonary, or cardiopulmonary (CP) modeling component (42) includes a microprocessor pro-programmed to: receive the measured values of the at least one monitored physiological variable; receive a value for at least one patient-specific medical image parameter generated from at least one medical image of the patient; compute values for the patient of unmonitored physiological variables based on the measured values for the patient of the monitored physiological variables and the patient-specific medical image parameter; and at least one of (1) display the computed values and (2) control a therapy device delivering therapy to the patient based on the computed values.
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