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Proteins with repetitive bacterial-IG-like (Big) domains present in Leptospira species

机译： Leptospira 物种中存在具有重复细菌-IG-样（大）结构域的蛋白质

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The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for BigL1, BigL2 and BigL3 proteins are used for the diagnosis and prevention of infection with Leptospira species that are capable of producing disease in humans and other mammals, including those of veterinary importance. 展开▼

机译：本发明涉及在Leptospira sp细菌中的三个分离的DNA分子，它们编码蛋白质BigL1，BigL2和BigL3，它们具有重复的细菌-Ig样（Big）结构域，并用于诊断，治疗和疫苗应用。根据本发明，分离的编码BigL1，BigL2和BigL3蛋白的分子被用于诊断和预防 Leptospira 物种的感染，这些物种能够在人和其他哺乳动物中产生疾病。兽医的重要性。展开▼

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公开/公告号US9932391B2

专利类型

公开/公告日2018-04-03

原文格式PDF

申请/专利权人 THE UNITED STATES OF AMERICA REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;CORNELL RESEARCH FOUNDATION INC.;FUNDAÇÃO OSWALDO CRUZ—FIOCRUZ;
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申请/专利号US201615334128

发明设计人 ALBERT I. KO;MITERMAYER GALVÃO REIS;JULIO HENRIQUE ROSA CRODA;ISADORA CRISTINA SIQUEIRA;DAVID A. HAAKE;JAMES MATSUNAGA;LEE W. RILEY;MICHELE BAROCCHI;TRACY ANN YOUNG;
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申请日2016-10-25

分类号G01N33/53;C07K16/12;C12Q1/68;C07H21/04;C07K14/20;G01N33/569;A61K39;

国家 US

入库时间 2022-08-21 12:55:45

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2. 用接头键合对具有免疫球蛋白G(IgG)的Fc部分的蛋白质具有亲和力的多个结构域之间而成的蛋白质 [P] . 中国专利： CN105814201A . 2016-07-27

3. PROTEINS WITH REPETITIVE BACTERIAL-IG-LIKE (BIG) DOMAINS PRESENT IN LEPTOSPIRA SPECIES [P] . 美国专利： US2018186867A1 . 2018-07-05

机译：钩端螺旋体物种中存在具有重复性细菌-IG-like（BIG）域的蛋白

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机译：钩端螺旋体物种中存在具有重复性细菌-IG-like（BIG）域的蛋白

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