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Methods of predicting the need for surgery in crohn's disease
Methods of predicting the need for surgery in crohn's disease
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机译:预测克罗恩病是否需要手术的方法
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摘要
The present invention relates to methods of predicting susceptibility to a severe form of Crohn's disease in an individual by determining the presence or absence of one or more risk variants. In one embodiment, the risk variants comprise a combination of genetic risk variants and clinical risk factors. In another embodiment, the genetic risk variants are at the IL12B genetic locus. In another embodiment, the severe form of Crohn's disease is characterized by a rapid progression to a condition requiring surgery for treatment.
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