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Isotopically-labeled solvents and the use of same in testing E-cigarettes
Isotopically-labeled solvents and the use of same in testing E-cigarettes
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机译:同位素标记的溶剂及其在测试电子烟中的用途
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摘要
Isotopically-labeled species of propylene glycol and glycerol are provided as solvents for use in electronic nicotine delivery systems (e.g., as disposed in a cartridge in an e-cigarette). The isotopically-labeled species are distinguishable from the non-isotopically-labeled species (e.g., by mass spectrometry). Thus, methods are provided for the measurement of the quantity of solvent or of a solvent heating by-product (e.g., formaldehyde, acetaldehyde), or of a metabolite of the drug, delivered to a user by analysis of blood samples taken subsequent to dosing by use of the electronic nicotine delivery system. An example of an isotopically-labeled species of propylene glycol for use in such measurement methods is [13C]3H8O2. A clinical study of e-cigarettes loaded with this isotopically-labeled species resulted in the following blood plasma concentration profiles in “vaping” subjects.
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机译:提供同位素标记的丙二醇和甘油作为溶剂,用于电子尼古丁递送系统(例如,放置在电子烟的药筒中)。同位素标记的物种可与非同位素标记的物种区分开(例如,通过质谱法)。因此,提供了用于通过分析给药后采集的血液样本来测量递送给使用者的溶剂或溶剂加热副产物(例如,甲醛,乙醛)或药物代谢物的量的方法。通过使用电子尼古丁传送系统。用于此类测量方法的丙二醇同位素标记的例子是[ 13 Sup> C] 3 Sub> H 8 Sub> O 2 Sub>。对装有这种同位素标记物种的电子烟进行的临床研究导致“吸烟”受试者的血浆浓度分布如下。
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