Methods for measuring concentrations of analytes in turbid solutions by applying turbidity corrections to raman observations

摘要

A method of measuring the concentration of an analyte in a turbid solution containing the analyte and a solvent is disclosed. The method includes determining a turbidity value for the turbid solution based on a Raman line intensity calibration data set for the solvent. The method further includes determining turbidity correction factor based on the turbidity value and a Raman line calibration data set for the analyte and applying the turbidity correction factor to the Raman line intensity of the analyte in the turbid solution and calculating a turbidity-corrected Raman line intensity for the analyte in the turbid solution. The turbidity-corrected Raman line intensity of the analyte in the turbid solution is then used to determine the concentration of the analyte in the turbid solution utilizing previously developed calibration data sets relating Raman line intensity to analyte concentration in solutions of negligible turbidity.