nucleic acid comprising or encoding a histone loop rod structure and a poly (a) sequence or polyadenylation signal to increase expression of a coded tumor antigen

摘要

Abstract: "Nucleic acid comprising or encoding a histone loop stem structure and a poly (a) sequence or a polyadenylation signal to increase expression of an encoded tumor antigen". The present invention relates to a nucleic acid sequence comprising or encoding a coding region encoding at least one peptide or protein comprising a tumor antigen or a fragment, variant or derivative thereof, at least one histone loop rod structure and a poly (a) sequence or a polyadenylation signal. furthermore, the present invention provides the use of nucleic acid to increase expression of said encoded peptide or protein. It also describes its use for the preparation of a pharmaceutical composition, especially a vaccine, for example for use in the treatment of cancerous diseases or tumors. The present invention also discloses a method for enhancing expression of a peptide or protein comprising a tumor antigen or fragment, variant or derivative thereof, with the nucleic acid comprising or encoding a histone loop-like structure and sequence. poly (a) or a polyadenylation signal.