abstract disclosed are respiratory syncytial virus (rsv) antigens including a recombinant rsv f protein stabilized in a prefusion conformation. also disclosed are nucleic acids encoding the antigens and methods of producing the antigens. methods for generating an immune response in a subject are also disclosed. in some embodiments, the method is a method for treating or preventing an rsv infection in a subject by administering a therapeutically effective amount of the antigen to the subject. 2-aminopyrimidin-6-ones and analogues exhibiting anticancer and antiproliferative activities are described compounds of formula I formula I which find utility in the treatment of cancer, autoimmune diseases and metabolic disorders of bone by inhibiting c-fms (csf-ir). , c-kit and / or pdgfr kinases. These compounds also find utility in the treatment of other c-fms, c-kit, or pdgfr-mediated mammalian diseases.
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