application, manipulation and optimization of systems, methods and compositions for targeting and modeling post-mitotic cell diseases and disorders

摘要

Patent Summary for “Application, Handling, and Optimization of Systems, Methods, and Compositions for Targeting and Modeling Dog Diseases and Disorders” post-mitotic squids � the invention provides the application, manipulation and optimization of systems, methods, and compositions for manipulation of sequences and / or target sequence activities. application systems and tissues or organs are provided that include post-mitotic cells that are intended as application sites. Vectors and vector systems are also provided, some of which encode one or more components of a crispr complex, as well as methods for the design and use of these vectors. Also provided are methods of directing the formation of the crispr complex in eukaryotic cells to ensure increased specificity for target recognition and avoid toxicity and for editing or modifying a target site at a genomic site. Of interest to change or improve the condition of a disease or condition.