PHB and blends of PHB PPG, used as a means of prolonged release of Simvastatin

摘要

The present invention describes the product, process, and the use of devices containing poii (3 - hidroxidobutirato) (PHB), polypropylene glycol (PPG) for the controlled release of statins.Preferably the simvastatin.The devices can be obtained by conventional processing of polymeric materials.As the polymeric matrix presents properties of thermoplastic that can be modeled and acquire shape according to the intended goal.When tested in the in vitro release.These materials are capable of releasing the simvastatin in a gradual and the presence of PPG in up to 10% by mass in relation to the PHB in the polymeric matrix of the devices release promotes the LiberaTion in times shorter.The products of this invention are biocompatible capable of interacting with living organisms without causing significant rejection, being suitable for applications in the pharmaceutical and biomedical applications.