nanoparticulate composition, artificial dendritic cell, method for stimulating or enhancing an immune response and method for treating cancer

摘要

nanoparticulate compositions are disclosed. nanoparticulate compositions typically include at least one, preferably two or more active agents, one of which is an immunomodulatory compound, charged, surface-bound and / or enclosed within a delivery vehicle. delivery vehicles may be nanolipogels which include a polymeric core and a lipid envelope or a biodegradable polymeric nanoparticle, such as a plga nanoparticle. Typically, at least one of the active agents is an immunomodulator that enhances a stimulating immune response or decreases a suppressing immune response. In some embodiments, the particle includes both an immunomodulator that enhances a stimulatory immune response and an immunomodulator that decreases a suppressive immune response. The particles can be decorated with a targeting fraction that improves delivery to a target cell. Methods for using the compositions to enhance an immune response and treat diseases such as cancer are also disclosed.