Artificial match type miRNA and its use for gene expression control

摘要

The present invention provides a novel artificial match type mirna using mirna. the artificial match type mirna is a single-stranded nucleic acid comprising an x region and a y region, and is configured such that: the 3? of region x and the 5th end? of the y region are connected by means of an adapter region having a non-nucleotide structure, the x region comprises a mature minna guide strip sequence, and the y region is single-stranded nucleic acid comprising the sequence that is completely complementary to region x. This artificial match type mirna makes it possible to inhibit expression of the target gene.