modified factor viii binding polypeptide, complex, pharmaceutical composition, methods for treating a coagulopathy, to produce a polypeptide comprising a modified vwf, and to increase vwf factor viii binding affinity and factor viii half-life, use of a modified polypeptide or complex, polynucleotide, plasmid or vector, and host cell.

摘要

The present invention provides a modified polypeptide that binds to factor viii. the modified polypeptide comprises a sequence as defined in sequence: 3 wherein the sequence comprises at least one change in position 1 or 3 such that the modified polypeptide binds to factor viii with a dissociation rate of at least 5 times lower. which is a reference polypeptide comprising an unmodified sequence id: 3.