kit, lyophilized antigen composition and method for preparation of an immunogenic composition

摘要

A dual formulation for neisseria meningitidis ("men-b") serogroup b vaccines is provided comprising: (i) an oil-in-water emulsion adjuvant and (ii) an immunogenic component of men-b in lyophilized form . men-b lyophilized antigens may be reconstituted in liquid form with adjuvant at the time of use, ready for administration to a patient. Such a formulation has been found to yield excellent results in terms of both stability and immunogenicity. the lyophilized component may also include one or more conjugated saccharides of n. meningitidis in serogroups a, c, w135 and / or y.