The complete method for placing the antibody of the immunoglobulin type is transmitted through the cell membrane into the cytoplasm, and use his

摘要

method for positioning, in cytoplasm, antibody containing complete immunoglobulin form penetrating antibody through the cell membrane and its use refers to a method of locating an intact immunoglobulin antibody in the cytosol when permeating cell membranes; a light chain variable region (vl) that induces an antibody in intact immunoglobulin format to penetrate the membrane of living cells and be located in the cytosol and an antibody that comprises it; to a biologically active molecule fused with the antibody and selected from the group consisting of peptides, proteins, small molecule drugs, nanoparticles and liposomes; a composition for the prevention, treatment or diagnosis of cancer, which comprises the antibody or an active biological molecule fused with the antibody and selected from the group consisting of peptides, proteins, small molecule drugs, nanoparticles and liposomes; to a polynucleotide that encodes the variable region of the light chain and the antibody and to a method for producing an antibody that penetrates cells and is located in the cytosol.