compositions and method for enhancing the initial pharmacokinetic release profile in vivo

摘要

A composition comprising (a) a particle population of an aripiprazole prodrug having a volume-based particle size (dv50) of less than 1,000 nm and (b) at least one surface stabilizer comprising an adsorbed component is disclosed. , which is adsorbed to the surface of aripiprazole prodrug particles, and a free component, available for solubilization of the aripiprazole prodrug. The surface stabilizer to prodrug ratio provides the ideal amount of free surface stabilizer for the purpose of producing a lead-in formula. Methods of treatment using the above composition are also disclosed.