hiv vaccines comprising one or more antisense antigens in the population

摘要

summary? hiv vaccines comprising one or more blunt antigens in the population? The present invention relates to hiv-1 vaccines that comprise a carrier and an antisense antigen in the population determined using the epigraph approach. hiv-1 vaccines are also provided which comprise a vehicle, a population dense antigen and a personalized antigen. Also provided are methods for designing and producing a hiv-1 vaccine for an individual comprising designing vaccine antigens to optimally cover diversity within a geographical area using an amino acid sequence generated using the epigraph approach and producing said vaccine antigen. designed. Also provided are methods for inducing an effector memory t cell response comprising designing one or more epigraph amino acid sequences, producing a vaccine comprising one or more epigraph amino acid sequences and a vector, and administering the vaccine to an individual. . Further provided are methods for treating hiv-1 in an individual comprising administering an effective amount of the described hiv-1 vaccines to the individual in need thereof.