methods for purification for removing metal ion impurities from a lanthanide metal complex from a lanthanide metal, for preparing a liquid pharmaceutical formulation and a magnetic resonance imaging contrast agent, elimination resin, and , use of an elimination resin.

摘要

The present invention relates to a method of removing impurities from metal ions, such as calcium, from macrocyclic chelating lanthanide metal complexes. The method uses an elimination resin to remove metal ions displaced from the chelator by an excess of lanthanide ions. Also provided is a method of preparing mri contrast agents from the purified lanthanide metal complex by the addition of a defined excess chelator.