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One kind of MEK kinase inhibitor of p-toluene sulfonate, its crystalline form and method of preparation
One kind of MEK kinase inhibitor of p-toluene sulfonate, its crystalline form and method of preparation
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机译:一种对甲苯磺酸的MEK激酶抑制剂,其晶型和制备方法
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摘要
The present invention relates to a p-toluenesulfonate for a mek kinase inhibitor, and a crystalline form thereof and a method of preparation thereof, which are described. specifically, a 2 - ((2-fluoro-4-iodophenyl) amino) -1-methyl-4 - ((6-methylpyridine-3-group) oxigroup) -6-carbonyl-1,6-di-p-toluenesulfonate -hydropyridine-3-formamide (a compound represented by formula (i)), and a crystal of form i and a preparation method for such are described. Form I crystal obtained from the compound represented by formula (I) (I) has good crystalline form stability and chemical stability, and a crystallization solvent used has low toxicity and low residue and may be better used in clinical treatment.
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