'Uses of nuc-1031 and method to determine if a cancer patient or a precancerous condition will benefit from cancer prevention or treatment with it.'

摘要

The invention provides nuc-1031 (gemcitabine [phenyl-benzoxy-1-alaninyl)] phosphate), a protoid derivative of gemcitabine, for use in targeting cancer stem cells. This targeting of cancer stem cells can be employed in the prevention or treatment of cancer. The invention also provides nuc-1031 for use in treating recurrent or refractory cancer in a human patient. Without being bound by any hypothesis, it is believed that nuc-1031's ability to target cancer stem cells contributes to its usefulness in the treatment of recurrent or refractory cancers.