L-ARGININE SALT CRYSTALLINE ACID (R) -2- (7- (4- CYCLOPENTYL-3- (TRIFLUOROMETHYL) BENZYLOXY) -1,2,3,4- TETRA-HYDROCYCLE-PENTA B INDOL-3- IL) ACETIC (COMPOUND 1) FOR USE IN DISORDERS ASSOCIATED WITH THE S1P1 RECEPTOR

摘要

The present invention relates, among other things, to a novel free plaque crystalline habit or morphology, processes for the preparation of the free plaque crystalline habit and uses of the free plaque crystalline habit of the acid l-arginine salt (r ) -2- (7- (4-cyclopentyl-3- (trifluoromethyl) benzyloxy) -1,2,3,4-tetrahydrocyclo-penta [b] indol-3-yl) acetic acid (compound 1) in the treatment of s1p1 receptor-associated disorders, for example, lymphocyte-mediated diseases and disorders, transplant rejection, autoimmune diseases and disorders, inflammatory diseases and disorders (for example, acute and chronic inflammatory conditions), cancer, and conditions characterized by an underlying defect in the vascular integrity or that are associated with angiogenesis, as may be pathological (for example, as may occur in inflammation, tumor development, and atherosclerosis).