binding agent-drug conjugates (adcs) and binding agent-prodrug conjugates (apds) having enzymatically cleavable groups

摘要

"drug-binding agent conjugates (adcs) and drug-binding agent conjugates (apcs) having enzymatically cleavable groups" The present invention relates to novel prodrug-binding agent (apdcs) conjugates, wherein the binding agents are conjugated to inactive kinesin spindle protein inhibitor precursor compounds, and to adcs antibody-drug conjugates and processes for the production of these aps and ads.