Liquid crystalline phases (lamellar and cubic) as a release system for topical use of Pro drugs: 5-aminolevulinic acid (5-ALA) and esters derived methyl, butyl, octyl and decile, hexil,Used in photodynamic therapy (PDT) and / or fotodiagnu00f3stico (FD)

摘要

"Liquid crystalline phases (lamellar and cubic) as a release system for topical use of Pro drugs: 5-aminolevulinic acid (5-ALA) and esters derived methyl, butyl, octyl and decile, hexil,Used in photodynamic therapy (PDT) and / or fotodiagnu00f3stico (FD).The liquid crystalline phases, lamellar and cubic, referred to in this patent, are essentially formed by: 95 to 60% by weight, relative to the total weight of the composition.A mixture of monogliceru00eddeos called monoleu00edna, containing 18 carbon acyl chain, and 5 to 40% by weight of water.This composition is, in the limit of temperature between 20 and 75 198 C, the texture of a liquid crystalline gel, and preferably, the cubic phase.The pro drugs incorporated in these phases, lamellar and cubic are 5-aminolevulinic acid (5-ALA) and esters derived methyl, butyl, octyl and decile, hexil,Or any other ester derivative of 5-ALA, in the proportion of 0.2 to 2% in relation to total composition or any other composition, so that the presence of pro drug does not cause any change in the structure of these phases.