Monoclonal antibodies or antibody fragment to human programmed death receptor PD-1, polynucleotide, method for producing said antibodies or antibody fragments, composition comprising them and use thereof

摘要

Antibodies which block the binding of human Programmed Death Receptor 1 (hPD-1) to its ligands (hPD-L1 or hPD-L2) and their variable region sequences are disclosed. A method of increasing the activity (or reducing downmodulation) of an immune response through the PD-1 pathway is also disclosed.