Oxime derivative cromona penetrating Brain therapy to levodopa induced dyskinesia

摘要

p The present Invention provides a cromona oxime Derivative of formula (i),It is a Modulator of the glutamate receptors in the nervous system are sensitive to amino acid neuroexcitatorio and presents a suitably High Brain exposure with oral administrationFor the Treatment or prevention of levodopa induced dyskinesia.The present Invention also provides an improved Therapy of Parkinson's disease, using the cromona oxime Derivative of formula (i) in combination with levodopa. / p