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Peptide sequences and compositions from Anopheles gambiase
Peptide sequences and compositions from Anopheles gambiase
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机译:冈比亚按蚊的肽序列和组成
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摘要
Provided is a polypeptide composition comprising one or more polypeptides, which polypeptides are immunogenic in a vertebrate such that they cause the vertebrate to produce immune system cells capable of recognising at least one epitope from an arthropod saliva protein fraction, wherein the arthropod saliva protein fraction has a mass of 40kDA or less, and wherein the polypeptides are selected independently from: the polypeptide sequences of SEQ ID 1-44 or sub-sequences from these sequences, the sub-sequences having 7 amino acids or more; or from polypeptide sequences having 85% homology or more with one or more of the above sequences and contained in one or more of the following databases: GenBank, Protein Data Bank (PDB), SwissProt, Protein Information Resource (PIR), Protein Research Foundation (PRF), or CDS translations of these.
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机译:本发明提供了包含一种或多种多肽的多肽组合物,该多肽在脊椎动物中具有免疫原性,从而使脊椎动物产生能够识别节肢动物唾液蛋白组分中至少一个表位的免疫系统细胞,其中节肢动物唾液蛋白组分具有质量为40kDA或更小,并且其中多肽独立地选自:SEQ ID 1-44的多肽序列或来自这些序列的子序列,这些子序列具有7个氨基酸或更多个氨基酸;要么来自与上述一个或多个序列具有85%或更高同源性的多肽序列,并包含在以下一个或多个数据库中:GenBank,蛋白质数据库(PDB),SwissProt,蛋白质信息资源(PIR),蛋白质研究基金会( PRF)或这些的CDS翻译。
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