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1,2-DISUBSTITUTED 4-AMINO-IMIDAZOQUINOLINES, PHARMACEUTICAL COMPOSITION COMPRISING SAME AND USE THEREOF AS Toll-LIKE RECEPTORS 7 (EMBODIMENTS)
1,2-DISUBSTITUTED 4-AMINO-IMIDAZOQUINOLINES, PHARMACEUTICAL COMPOSITION COMPRISING SAME AND USE THEREOF AS Toll-LIKE RECEPTORS 7 (EMBODIMENTS)
Disclosed are imidazoquinolines of formula (I); ;that contain substituted amine functionalities at 1-position (wherein A, B and R1 are disclosed in the claims) and that are effective as Toll-like Receptor 7 activators (TLR7). Also disclosed are pharmaceutical compositions comprising the compounds of formula (I) and the use of these compounds and compositions for manufacturing medicaments and for treating diseases sensitive to TLR7 activation.
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机译：公开了式（I）的咪唑并喹啉; <图像文件=“ IMGA0002.GIF” he =“ 34” imgContent =“绘图” imgFormat =“ GIF” wi =“ 31” /> ;其在1-位含有取代的胺官能团（其中权利要求中公开了A，B和R 1 ），并且作为Toll样受体7活化剂（TLR7）有效。还公开了包含式（I）的化合物的药物组合物，以及这些化合物和组合物在制备药物和治疗对TLR7活化敏感的疾病中的用途。
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