VACCINE AGAINST THE VIRUS OF THE DIAGRAM (VL) BASED ON A RECOMBINANT MODIFIED VIRUS OF ANPARA VOCUS ANKARA (MVA)

摘要

The present invention relates to modified poxvirus vectors and to methods for their preparation and use. In particular, the invention relates to a vaccine against infection of IH on the basis of a recombinant modified vaccinia virus Ankara (based on MVA) and related products, methods and uses. Specifically, the present invention relates to genetically modified (recombinant) MVA vectors containing at least one heterologous nucleotide sequence that encodes an antigenic determinant of the VL protein. In addition, the invention relates to products, methods and their use, for example, suitable for inducing a protective immune response in a patient.