首页>
外国专利>
Genetically modified mouse that expresses human il-6
Genetically modified mouse that expresses human il-6
展开▼
机译:表达人类il-6的转基因小鼠
展开▼
页面导航
摘要
著录项
相似文献
摘要
Mice that comprise a replacement of endogenous mouse IL-6 and/or IL-6 receptor genes are described, and methods for making and using the mice. Mice comprising a replacement at an endogenous IL-6R± locus of mouse ectodomain-encoding sequence with human ectodomain-encoding sequence is provided. Mice comprising a human IL-6 gene under control of mouse IL-6 regulatory elements is also provided, including mice that have a replacement of mouse IL-6-encoding sequence with human IL-6-encoding sequence at an endogenous mouse IL-6 locus.
展开▼