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Engineered clostridium botulinum toxin adapted to deliver molecules into selected cells
Engineered clostridium botulinum toxin adapted to deliver molecules into selected cells
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机译:工程肉毒梭菌毒素适用于将分子递送到选定的细胞中
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摘要
An engineered payload-delivery system includes a target cell binding unit, covalently bound to a pore forming unit, and a payload portion adapted with a region capable of non-covalently binding to the pore forming unit. The pore forming unit is derived from a particular sub-serotype of Clostridium toxin, while the payload region is derived from a different sub-serotype of Clostridium toxin. The disclosed chimeric protein-based composition is capable of specifically delivering payload to neural cells.
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