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Combination comprising an aminothiolester compound or a pharmaceutically acceptable salt thereof and a compound able to increase the h2o2 level in cancer cells of a subject
Combination comprising an aminothiolester compound or a pharmaceutically acceptable salt thereof and a compound able to increase the h2o2 level in cancer cells of a subject
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机译:包含氨基硫羟酸酯化合物或其药学上可接受的盐和能够增加受试者癌细胞中h2o2水平的化合物的组合
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摘要
The present invention relates to a combination comprising an aminothiolester compound or a pharmaceutically acceptable salt thereof, in particular the S-methyl 4-(dimethylamino)-4-methylpent-2-ynethioate or a pharmaceutically acceptable salt thereof, and more particularly the 4-(Dimethylamino)-4-methyl-2-pentynethioic acid S-methyl ester fumarate, and a compound able to increase H2O2 level in cancer cells of a subject, in particular for use for the treatment of cancer in a subject, wherein cancer cells of said subject do not overproduce H2O2 in comparison to a control value and have a level of GSH below 5 nmol for 25000 cells.
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机译:本发明涉及一种组合,其包含氨基硫酯化合物或其药学上可接受的盐,特别是S-甲基4-(二甲基氨基)-4-甲基戊-2-炔硫醇酸酯或其药学上可接受的盐,更特别地是4- (二甲基氨基)-4-甲基-2-戊炔硫磺酸富马酸酯,以及能够增加受试者癌细胞中H2O2水平的化合物,特别是用于治疗受试者的癌症,其中所述受试者与对照值相比没有过量产生H 2 O 2,并且对于25000个细胞而言具有低于5nmol的GSH水平。
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