LIPID NANOCAPSULE LOADED WITH CORTICOSTEROIDS FOR IMPROVING BIOAVAILABILITY AND EFFICACY IN TREATMENT OF CRONH'S DISEASE

摘要

The basic aim of invention concerns develop lipidic nanocapsules for effective treatments of Crohn's disease with the enhance bioavailability of corticosteroids. Mean particle size of develop formulation was found size less than 120 nm and Entrapment efficiency of nanocapsules more than 75%. Nanocapsules core consist of oil, lipid and drug. Nanocapsules improve the oral bioavailability and first pass metabolism of drug. Said lipid nanocapsules prepared by phase inversion method and modified solvent evaporation.