A HUMAN PROGENITOR CELLULAR PLATFORM FOR DRUG DISCOVERY

摘要

The present invention includes systems and methods for assaying small molecules using living homogenous human derived progenitor cells for predicting the cellular differentiation or regeneration capacities. In one aspect, the invention provides cellular differentiation capacity predicting system or platform comprising a multi-welled diagnostic plate wherein each such well is coated with cultured homogenous progenitor cells, different medium and other substrates for predicting the characteristics of the sample molecule. In another aspect, the invention provides cellular assays that use culturing of donor and patient derived specific mesenchymal stem cells to detect the differentiation capacities of a molecule. In some preferred embodiment, the assays are designed to predict the drug discovery road map. In some more preferred embodiment, it is used for phenotypic and genotypic throughput assaying of investigational drug candidates on predictive human derived progenitor cellular platform also.