PROCESS FOR PRODUCING (±)-3a,6,6,9a- TETRAMETHYL DODECAHYDRONAPHTH O2,1-b FURANS

摘要

pThe present invention relates to a process for producing (±)-3a,6,6,9a-tetramethyl dodecahydronaphtho[2,l-b]furans from crude (±)-3a,6,6,9a-tetramethyl dodecahydronaphtho[2,l-b]furans obtained by subjecting (±)-3a,6,6,9a-tetramethyl dodecahydronaphtho[2,l-b]furan-2(lH)-ones which are produced by cyclizing a homofarnesylic acid amide or a monocyclohomofarnesylic acid amide in the presence of an acid agent and then hydrolyzing the cyclized product, to reduction reaction and then to cyclization reaction, said process including (i) an alkali treatment step in which the crude (±)-3a,6,6,9a-tetramethyl dodecahydronaphtho[2,l-b]furans are heated in the presence of an alcohol and a metal hydroxide; and (ii) a washing treatment step in which the crude (±)-3a,6,6,9a-tetramethyl dodecahydronaphtho[2,l-b]furans are washed with an aqueous acid solution. The thus obtained (±)-3a,6,6,9a-tetramethyl dodecahydronaphtho[2,l-b]furans have a less off-odor and hardly suffer from deterioration of their smell during storage./p[WO2010092872A1]