首页>
外国专利>
HYDRATED N FULLERENE AMINO ACIDS METHOD FOR PRODUCING THE LATTER AND PHARMACEUTICAL COMPOSITIONS ON THE BASIS THEREOF
HYDRATED N FULLERENE AMINO ACIDS METHOD FOR PRODUCING THE LATTER AND PHARMACEUTICAL COMPOSITIONS ON THE BASIS THEREOF
展开▼
机译:基于水合N-富勒烯氨基酸的方法生产皮革和药物组合物
展开▼
页面导航
摘要
著录项
相似文献
摘要
pThe invention relates to the pharmaceutical industry and to medicine, specifically to novel hydrated amino-acid derivatives of fullerene C60 of general formula C60(H)3{NH(CH2)nCOOH}3.xH2O, where C60-fullerene, n=5, 6, 7, x=8-10, and also to a method for producing said derivatives, and to the production of pharmaceutical compositions on the basis thereof. Hydrated N-fullerene amino acids are formed in the interaction of fullerene with 15 times the molar excess of anhydrous potassium salts of amino acids in a medium of organic aromatic solvent with slow addition to the resultant suspension of an interphase catalyst and with mixing and heating to a temperature not exceeding 60° C. until the solution is completely decolorized and a solid residue formed, after which the latter is separated out, and then 0.8 M of aqueous solutions of potassium salts of fullerene amino-acid derivatives is treated with a solution of organic or mineral acids, followed by centrifugation, rinsing and drying of the residue. A pharmaceutical composition which exhibits activity against the herpes virus, flu viruses of various origin and HIV, and also anti-tumor and anti-psoriatic activity, comprising, as active substance, an effective quantity of hydrated N-fullerene amino acids./p [US2013165692A1]
展开▼