NEW PROCESS FOR THE SYNTHESIS OF 3-(2- BROMO-4,5- DIMETHOXYPHENYL) PROPANENITRILE, AND APPLICATION IN THE SYNTHESIS OF IV ABRADINE AND ADDITION SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID

摘要

Preparation of dimethoxyphenyl propanenitrile compound (I) involves reacting 3-(3,4-dimethoxyphenyl)propanenitrile with N-bromosuccinimide in the presence of an organic solvent. Preparation of dimethoxyphenyl propanenitrile compound of formula (I) involves reacting 3-(3,4-dimethoxyphenyl)propanenitrile with N-bromosuccinimide in the presence of an organic solvent. An independent claim is included for preparation of ivabradine, its salts and hydrate, which involves reacting dimethoxyphenyl propanenitrile compound with acid chosen from hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, acetic acid, trifluoroacetic acid, lactic acid, pyruvic acid, malonic acid, succinic acid, glutaric acid, fumaric acid, tartaric acid, maleic acid, citric acid, ascorbic acid, oxalic acid, methanesulfonic acid, benzenesulfonic acid and camphoric acid, or their salt. ACTIVITY : Cardiant; Vasotropic; Antianginal; Antiarrhythmic. No biological data given. MECHANISM OF ACTION : None given. EP2719689A1