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COMPOSITION AND METHODS FOR REGULATING INHIBITORY INTERACTIONS IN GENETICALLY ENGINEERED CELLS.
COMPOSITION AND METHODS FOR REGULATING INHIBITORY INTERACTIONS IN GENETICALLY ENGINEERED CELLS.
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机译:调节基因工程细胞中抑制相互作用的组合物和方法。
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摘要
Provided are engineered cells for adoptive therapy, including T cells. Also provided are methods and compositions for engineering and producing the cells, compositions containing the cells, and method for their administration to subjects. In some embodiments, the cells, such as T cells, contain genetically engineered antigen receptors that specifically bind to antigens, such as a chimeric antigen receptor (CAR). In some embodiments, the cells, such as a CAR-expressing T cell, contains an agent that is capable of reducing an inhibitory effect by repressing and/or disrupting a gene in an engineered cell, such as a gene involved in inhibiting the immune response. In some embodiments, features of the cells and methods provide for increased or improved activity, efficacy and/or persistence.
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