RECOMBINANT LISTERIA VACCINE STRAINS AND METHODS OF USING THE SAME IN CANCER IMMUNOTHERAPY.

摘要

A method of treating a cervical cancer in a human subject, the method comprising the step of administering to said subject a combination therapy comprising chemo-radiation and a recombinant Listeria strain, said Listeria strain comprising a recombinant nucleic acid, said nucleic acid comprising a first open reading frame encoding a recombinant polypeptide comprising an N-terminal fragment of an LLO protein fused to an HPV-E7 antigen or a fragment thereof, wherein said Listeria strain is administered at an initial dose of 5x109 colony-forming units (CFU), and wherein a subsequent dose of Listeria strain is administered to said patient every 3 weeks, thereby treating said cervical cancer in said human subject.