CHITOSAN BIODEGRADABLE BILAYER SCAFFOLD AS A SUBSTITUTE OF DURA MATER.

摘要

The present invention refers to a biological membrane of chitosan in a water resistant bilayer for repairing the meningeal tissue (dura mater) and as a scaffold for inducing mesothelial cells and fibroblasts, which would promote the development of specific cells of the biological tissue of dura mater. Due to the development of the present invention, the obtained membrane will preserve the biological active principles, including the phagocyte activation, cytolysis, cytostatic, antibody production, cytosine production, mitogenic activity, antitumor activity and antimicrobial activity, without substantially altering said principles, these being intrinsic characteristics of chitosan and chitin derivatives, therefore obtaining a product that retain the beneficial properties of the raw material, also presenting added beneficial characteristics that promote a synergy between the initial benefits and those added, such as the characteristics required by a suitable dura substitute, a water-resi stant dura closing, admitting infiltration by fibrocytes, fibroblasts, macrophages, lymphocytes, newly formed vessels, as well as the systematic and progressive deposit of collagen fibers, without causing a keloid scar.