PEPTIDES FROM SCORPION VAEJOVIS PUNCTATUS AS ANTIBIOTICS AGAINST MYCOBACTERIUM TUBERCULOSIS AND FURTHER PATHOGEN BACTERIA AND YEASTS.

摘要

The present invention refers to two novel synthetic peptides without disulfide bridges, cloned, synthesized, identified and characterized, also referring to the design of two novel variants of the same. The parental peptides were obtained from the total RNA obtained from the venom glands of the Mexican scorpion Vaejovis punctatus, the invention also referring to the use thereof as an antibiotic agent. These peptides may be produced by a chemical synthesis or by techniques of the recombinant RNA and are known in the present invention as: VpAmp1.0, VpAmp2.0, VpAmp1.1 and VpAmp2.1 (SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, and SEQ ID NO: 4, respectively). The invention comprises their use as antibiotics for controlling bacterial infections, particularly multidrug-resistant Mycobacterium tuberculosis strains and other pathogen bacteria, selected in order to represent the groups of different Gram (-) and Gram (+) pathogens and a yeast group, some of them known by their elevated virulence o r by their resistance to commercial antibiotics, also referring to the pharmaceutical compositions that comprise said peptides, which may be used as a unique antibiotic agent or in combination with commercial antibiotics.