Pharmaceutical formulations of Rapid Disintegration pre Compacted compounds with low oral bioavailability. Preparation Process

摘要

An attrition mill that includes a grinding chamber having a plurality of grinding elements and an internal classification and separation stage. The mill also includes at least one grinding element providing a larger flow path therethrough, when compared to other of the grinding elements. In other embodiments, mill includes at least one grinding element having an open area in the grinding element created to allow a larger flow path as a proportion of the grinding element surface area without such allowance and in the range of from 15% to equal to or less than 100%.